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treatmentVerified Apr 13, 2026

PicoSure Laser

8.0/10

PicoSure is Cynosure's picosecond laser platform that delivers ultra-short pulses (trillionths of a second) of 755nm alexandrite laser energy. Unlike traditional nanosecond lasers that rely on photothermal damage, picosecond pulses create photomechanical (pressure wave) disruption, shattering pigment and stimulating collagen without excessive heat. The Focus Lens Array creates microscopic injury zones surrounded by untreated tissue, triggering a signaling cascade called Cell Signaling that induces new collagen and elastin production.

PicoSure is FDA-cleared for tattoo removal, acne scars, wrinkles, and benign pigmented lesions. For pigmentation issues like melasma, sun spots, and post-inflammatory hyperpigmentation, the picosecond mechanism is gentler than traditional Q-switched lasers with lower risk of post-inflammatory hyperpigmentation, making it safer for darker skin tones. For skin rejuvenation, the Focus Lens creates a pattern of tiny LIOB (laser-induced optical breakdown) zones that stimulate collagen without breaking the skin surface.

Treatment cost ranges from $300-600 per session for skin rejuvenation and $200-500 per session for pigmentation, with 3-6 sessions typically needed. Downtime is minimal — mild redness and swelling for 24-48 hours. PicoSure competes with Cutera's enlighten, Syneron's PicoWay, and Lutronic's Hollywood Spectra in the picosecond laser market.

Key Details

How It WorksPicosecond alexandrite laser (755nm); photomechanical disruption; Focus Lens Array creates LIOB zones; Cell Signaling cascade
Cost (Low)$300
Cost (High)$600
Sessions Needed3-6 sessions, 4-6 weeks apart
Downtime2 days
Results TimelineImprovement visible after first session; optimal results at 3-6 months
Pain Level4/10
Best ForTattoo removal, Acne scars, Hyperpigmentation, Melasma, Skin rejuvenation, Sun damage, Fine lines
FDA ClearedYes
Treatment Duration20 min
MaintenanceMaintenance sessions every 6-12 months

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